As the foremost advocacy organization for businesses in the Fox Cities, the Chamber actively works to promote and cultivate a thriving business climate while protecting and advancing the interest of the members and the community as a whole. The Fox Cities Chamber works in conjunction with citizens, businesses, educational and governmental partners to provide a positive business environment and improve the quality of life in the Fox Valley.

The goal of the Fox Cities Chamber is to provide leadership and to serve as a catalyst in uniting organizations, groups and individuals for effective action where there are challenges and opportunities. By working together and pooling collective knowledge, time and resources, great accomplishments can be realized. The Fox Cities Chamber of Commerce primarily serves businesses of all sizes operating in or doing business in the following areas: Appleton, Kaukauna, Menasha and Neenah; the towns of Buchanan, Clayton, Grand Chute, Greenville, Harrison, Kaukauna, Menasha, Neenah and Vandenbroek, and the villages of Combined Locks, Hortonville, Kimberly, Little Chute and Sherwood.